Aneuploidy is a major cause of embryonic failure and miscarriage. A new study identifies genetic variants of ELL3 associated with miscarriage and discovers a novel role for ELL3 in female meiosis.
The authors present a solid statistical framework for using sibling phenotype data to assess whether there is evidence for de novo or rare variants causing extreme trait values. Their valuable method ...
Methods: We conducted a retrospective analysis of in vitro fertilization (IVF) cycles performed between 2015 and 2022, involving 773 female patients who underwent IVF and pre-implantation genetic ...
Samples were equimolar pooled and sequenced to a target 0.1× coverage using the Illumina NextSeq 500. The following measurements were made to compare the tissue types of interest: Genomic aneuploidy: ...