Pathogenic mechanisms in scleritis are poorly understood, but enzymatic degradation of collagen fibrils by resident cells and infiltrating leukocytes seems to be a key feature. Several forms of ...

Aims To describe and compare clinical features, complications and outcomes in patients with granulomatosis with polyangiitis (GPA)-associated scleritis with those seen in idiopathic and other ...

Research in mice has shown that NPSLE-like symptoms and olfactory impairment might be induced by autoimmune mechanisms that target specific areas of the brain, but this has not been explored.

Researchers discovered a previously unknown mechanism that may drive tissue ... block this harmful pathway in patients with autoimmune and inflammatory diseases. Results are published in Nature.

You will be redirected to our submission process. This Research Topic is the third volume of the “Pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease”. Please see the ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

These results confirm the strong Phase 1 and preclinical data package, underscoring the potential breadth and depth of Nck modulation, a completely novel mechanism in autoimmune disease.

Below, we discuss the evidence for and against each of these ideas. Many mechanisms protect tissues from autoimmune damage. These include relative isolation from the immune system and inhibition ...

Autoimmune disorders in children can cause symptoms often mistaken for common childhood illnesses. More precise diagnoses and increased awareness have led to better management. Parents should ...

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

Figure 1 Mechanisms of pathogen avoidance. A variety of comprehensive mechanisms are in place to regulate pathogens avoidance, which include those caused by the alteration of aerotaxis, intestinal ...