Abstract: In drug discovery and development, predicting drug properties greatly influences the selection and optimization of lead compounds. Drug solubility and biotransformation by cytochrome P450 ...

Drug addiction is a condition in which there is uncontrolled use of a substance with a harmful outcome. Drugs overstimulate the brain’s reward circuit, producing pleasure or euphoria. With repeated ...

Interestingly, these six drugs were found to share common substructures (a nitro group in entacapone ... S-acetylthiorphan and thiorphan in both the monoculture assay and simulated human digestive ...

You may receive a combination of therapies or something else entirely. Oncology (cancer) drugs include a range of therapies and medications, such as chemotherapy drugs, targeted therapies ...

The newest weight-loss drugs, Wegovy and Zepbound, are incredibly popular. But doctors are still learning about all of the ways they affect the body—both helpful and harmful—beyond reducing ...

A literature review was performed to collect information on the role of pharmacogenetics in six proposed teratogenic mechanisms associated with drug use during pregnancy: folate antagonism ...

Weight-loss drugs like Ozempic may decrease your risk of developing 42 health conditions, but increase your chance of experiencing 19 others, according to one of the most comprehensive studies-of ...

Formally, these drugs are known as glucagon-like peptide-1 receptor agonists (GLP-1RA) and include Mounjaro and Zepbound. Informally, media, patients and even some physicians have dubbed GLP-1 ...

No writing assistance was utilized in the production of this manuscript. Adverse drug reactions (ADRs) are a major preventable public health problem. Better identification of ADRs can save money ...