The effector functions resulting from this complement activation are ... but not identical to fragments generated by the complement cascade and are biologically active. Figure 13. Complement ...

Surface-bound C4b and C3b are opsonic, as are degradation fragments of C3b (not depicted), which associate with complement receptors (CR1,3,4). C3a and C5a are anaphylactic ... The latter may also ...

By targeting the C5a receptor, Danicopan helps modulate the overactive immune response associated ... 3 Glomerulopathy (C3G), highlighting its role in reducing disease progression and improving kidney ...

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

Neutrophils can themselves produce an array of inflammatory mediators, including cytokines, chemokines and complement; these cells also express Fc receptors, which can bind and possibly transport ...

THE use of the complement-fixation test in serologic investigation serves as a frequent reminder to the physician of the existence of the complement system. It is probable that despite the ...

aPsoriasis Research and Treatment Center, Department of Dermatology, Venereology and Allergology and Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie ...

This may be because of complement deposition on autologous red ... and are very unlikely to be life-threatening. C3a and C5a act on mononuclear phagocytic cells and neutrophils to stimulate ...

Here, the storage pool is decreased, neutrophils are less able to degranulate, have a reduced migratory capacity and are less able to release NETs. Less is known about neutrophil function from older ...