该方法利用肝素钠干扰 Cas12a 与 crRNA（CRISPR RNA）的结合过程，精准调节 Cas12 的顺式切割能力，等温扩增产物的积累会产生明显荧光信号。此外，这种通用检测方法适用于经典和非最优的前间区序列邻近基序（PAM），以及多种 Cas12a 亚型，如 LbCas12a、AsCas12a 和 ...

It is the most studied CRISPR gene editing technique, even if others exist like CRISPR-Cas12 or Cas13. The company was founded in 2017 with a focus on developing the technology of “base editing”.

By creating gene editors not found in nature, or optimizing existing editors, AI can improve the accuracy, effectiveness, and accessibility of gene editing.

CRISPR-based detection has long been challenged by the separation of amplification and detection steps. In this study, Cheng et al., show that heparin sodium modulates Cas12 cleavage activity and ...

Genetic engineering of animals has been recently revolutionized with the development of genome editing tools such as CRISPR-Cas9 and other CRISPR systems like Cas12 and Cas13. Genome editing provides ...

A pipeline for the analysis of CRISPR edited data. It allows the evaluation of the quality of gene editing experiments using targeted next generation sequencing (NGS) data (`targeted`) as well as the ...

CRISPR-Cas9 is one of the biggest discoveries of the 21st century. Since it was developed in 2012, this gene-editing tool has revolutionized biology research, making it easier to study disease and ...

CRISPR Therapeutics' stock decline is likely influenced by Editas Medicine's struggles, but CRISPR remains a distinct and stronger company with a promising long-term outlook. CRISPR's strategic ...

Shares of CRISPR Therapeutics CRSP have lost more than 30% in the past year. Though the stock soared at the onset of 2024, thanks to the FDA approval of its one-shot gene therapy Casgevy for two ...

The emergent field of CRISPR/Cas sensing technology is showing promise as a new paradigm in clinical diagnostics, although widespread clinical adoption remains limited. This perspective paper ...