Nicotine withdrawal induces behavioral symptoms such as tremors and shaking. Suppressing striatal cholinergic interneurons or administering the muscarinic antagonist Procyclidine significantly reduces ...

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

Dr. Heh-In Im at the Center for Brain Disorders of the Korea Institute of Science and Technology (KIST) has identified a novel brain region and neural mechanism involved in regulating nicotine ...

The drug – a selective muscarinic M4 receptor positive allosteric modulator (PAM) – is designed to have limited effect on dopamine neurotransmission, a mechanism thought to contribute to ...

The US regulator has cleared the combination of muscarinic M1 and M4 agonist xanomeline ... so Cobenfy's action on cholinergic receptors offers a brand new way to treat the disorder, which affects ...

Ltd. ("Nxera” or "the Company”; TSE 4565) is pleased to report on progress being made by Neurocrine Biosciences, Inc. ("Neurocrine”) regarding the clinical development of its partnered muscarinic ...