在AMPLIFY临床试验中，研究人员纳入了包括27个国家的800多名从未治疗的CLL患者，并将给予化疗的疗法与新型全药片疗法进行比较研究；针对CLL的标准化疗策略加上免疫疗法利妥昔单抗（rituximab）需要患者进行长时间的注射，并可能会引起长期的免疫抑制和其它令人不愉快的副作用发生。研究者John ...

本研究首次描述了非洲血统 CLL 患者的白血病遗传和转录组特征。与欧洲血统 CLL 相比，非洲血统 CLL 具有更高的基因组复杂性，BRCC3、NOTCH1、NXF1 和 NFKBIE 等基因的突变患病率增加，同时存在 NF - κB 信号转录富集和端粒侵蚀增加的现象。

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