The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role. C3a/C3aR has dual roles and may exert ...

C3(H 2 O) will bind to these platforms and will initiate local complement activation and C3b deposition. The amplification loop will generate C3a and C5a, which upon binding to their receptors ...

Neutrophils can themselves produce an array of inflammatory mediators, including cytokines, chemokines and complement; these cells also express Fc receptors, which can bind and possibly transport ...

C3.ai stock jumped more than 6% Tuesday, and have recovered from a rout in artificial intelligence stocks last week. Is C3.ai stock a buy now? Shares fell after previously hitting a resistance at ...

The US regulator has cleared Fabhalta (iptacopan) for the reduction of proteinuria in adults with primary IgAN who are at risk of rapid disease progression, making it the first complement ...

building the case for the drug as a new oral therapy for diseases caused by disorders of the complement system. The new data – in rare kidney disease IgA nephropathy (IgAN) – comes from the ...

It was recommended that patients receive antimalarial medications, an ACE inhibitor or angiotensin receptor blocker, calcium and vitamin D at stable doses ... levels of autoantibodies and serum ...