Pravastatin is one of a class of lipid-lowering compounds, the 3-hydroxy-3methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors ... is not carried out by the cytochrome P450 3A4 enzymes ...

Purpose: The basic concepts of pharmacogenetics, pharmacogenetic study approaches, factors to consider when applying pharmacogenetic discoveries to patient care, and potential roles for ...