Detection of DNA damage by ATR is one means of ATR activation therefore leading to cell cycle arrest, thus preventing cells with DNA lesions from replicating. This investigation centred on the ...

In hepatocellular carcinoma, the cGAS-STING pathway is activated by DNA damage, leading to IFN-1 release which in turn activates tumor-specific CD8 + T cell and helps induce systemic tumor immunity.

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

Get Instant Summarized Text (Gist) DNA damage in healthy cells can persist unrepaired for years, challenging traditional views on mutation formation. This persistence allows multiple opportunities ...

For decades, we’ve believed the bright redness of sunburn — along with its irritating sting and peeling ... and pain of sunburn may stem from damage to RNA, not DNA. “Sunburn damages the ...

But recent research has revealed something unexpected – some types of DNA damage can dodge these repair mechanisms and lurk in our cells for years, creating multiple opportunities for cancer-causing ...

Whether it’s from a lazy beach day or an exhilarating hike, the aftermath tells a singular tale – crimson skin and a nagging sting. We’ve long believed that stepping out into ... have made surprising ...

DNA damage can persist unrepaired for years, particularly in blood stem cells, increasing the risk of mutations and cancer. This discovery challenges traditional views on mutation processes and ...

"Sunburn damages the DNA, leading to cell death and inflammation. So the textbooks say. But in this study we were surprised to learn that this is a result of damage to the RNA, not the DNA that ...