This inhibition was removed in depolarized neurons, and such activity-dependent derepression was a primary requirement for their dendritic targeting. Here we characterized two opposite signals in ...

Derepression of C-pro transcription in sir2 causes RNA PolII to push the Mcm helicase complex from its normal location (arrow labeled “A”) to the right, with the most prominent signals arising at the ...

The cerebral cortex is the seat of complex brain functions and is a highly organized and compartmentalized structure. Its development relies on several progenitor types. These cells have specific ...

1 State Key Laboratory of Tree Genetics and Breeding, Engineering Technology Research Center of Black Locust of National Forestry and Grassland Administration, College of Biological Sciences and ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Background Azoospermia is diagnosed when sperm cells are completely absent in the ejaculate even after centrifugation. It is identified in approximately 1% of all men and in 10%–20% of infertile males ...

Copyright: © 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.