After missing the primary endpoint in the Phase IIb SYMMETRY trial, Akero Therapeutics’ lead molecule, efruxifermin, showed ...

FGF21 is a mediator of the fasting response ... This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer ...

A gut microbe could naturally regulate sugar cravings and blood sugar levels, offering a promising alternative to drugs like Ozempic.

Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics ...

The drug, a small molecule formulated as a once-daily pill ... EFX is a fusion protein engineered to mimic FGF21, a protein native to the body that regulates energy expenditure and the ...

Glucose homeostasis regulation is the core of T2DM treatment, this review highlights a new signaling molecule ... results in higher expression of Fgf21 in the liver, thereby improving glucose ...

It is a long-acting glycopegylated fibroblast growth factor 21 (FGF21) analog. The drug candidate acts by targeting FGF21R (composed of co-receptors FGFR1c, 2c and 3c and KLB). It is administered ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.