These findings are valuable, despite being mostly descriptive, as they point to a relevant function of SVZ newborn astrocytes in the modulation of the glial scar after brain ischemia. The methods ... ...

However, the activation of gliogenesis and the role of newly formed astrocytes in the post-ischemic scenario remain subjects of debate. We have previously demonstrated that adenosine release after ...

The aim of this study was to evaluate the effects of R1 on neurogenesis and long-term functional recovery after ischemic stroke. We used male Sprague-Dawley rats subjected to middle cerebral artery ...

Objective: Identification and validation of blood-based biomarkers for the diagnosis and prognosis of mild traumatic brain injury (mTBI) is of critical importance. There have been calls for more ...

These results suggest that gabapentin effectively reduces acute seizures and injury after ischemia in the immature brain. When analyzed by animal sex, the data suggest that gabapentin may more ...

Here, we highlight the complex molecular signaling that takes place in neurons, glial cells and the blood-brain barrier following ischemic insult. We also describe the evidence of TRPM2 ...

(Method): Rats were subjected to permanent left middle cerebral artery occlusion ... to decrease from 7 days after pMCAO. miR-204-5p mimic group showed a tendency of ameliorated functional dysfunction ...

Additionally, CRISPR/Cas gene editing was applied to healthy stem cells to study the roles of GFAP and vimentin. The absence of both proteins impaired organoid development, particularly in the cortex.

creating a grey area in which small bleeding strokes might not be identified or mistaken for ischemic strokes in elderly patients. "This study reveals that levels of GFAP, a marker for brain ...

First, the rodent brain is not gyrencephalic, with sulci and gyri, like the human brain. Instead, its cortex is smooth ... work from models of cerebral ischemia after stroke.