Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

Discussion: These results suggest that SESN2 is a negative regulator of ferroptosis. Enhancing the expression of SESN2 can alleviate ferroptosis through the activation of the System Xc−/GPX4 pathway.

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

Endometrial cancer (EC) ranks as the second most prevalent gynecologic malignancy globally, with approximately 189,000 new ...

Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China ...

【导读】S-棕榈酰化是一种可逆的、广泛存在的翻译后修饰，但人们对其在调控铁变态反应中的作用却知之甚少。在这项研究中，团队阐明了铁变态反应的重要调节因子GPX4在半胱氨酸66上可逆地发生棕榈酰化。2025年1月20日， 深圳湾实验室尹成骞教授团队在期刊 ...

(J) The comparison of GSH:GSSG ratio between JIMT1 and SKBR3. Ferroptosis sensitivity of HER2 positive breast cancer with different trastuzumab response. (A-B) Knockdown of SLC7A11 (A) and GPX4 (B) ...

We further treated the cells with CHIR99021, an activator of the Wnt signaling pathway. The results showed that CHIR99021 activated the GSK3β/β-catenin signaling pathway and reversed the PFOA-induced ...