Department of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Otto-Hahn-Strasse 4a, Dortmund 44227, ...

The first part – which was approved in January – covered the use of the drug in GIST patients with a platelet-driven growth factor receptor alpha (PDGFRa) exon 18 mutation, including PDGFRA ...

The tyrosine kinase inhibitor imatinib targets the human KIT receptor and the platelet-derived growth factor receptor-α. This drug exhibits impressive antitumor effects against GIST and has ...

Incidence peaks in individuals over 70 years of age (3.06/100,000). 6 The Carney triad, caused by mutation of the SDH gene, is a rare, nonhereditary condition characterized by the presence of 3 ...

As the deputy editor who oversees Forbes Vetted’s beauty vertical, I rounded up the best teeth whitening kits based on recommendations from dentists and insights from five staff testers.

February 14, 2025 • Parenting can keep you on your toes all day. But if you find it so physically and mentally draining you can't enjoy family time, it may be a sign of burnout. Here's what you ...

[25] In view of these data, imatinib has become the first-line treatment for patients presenting with advanced GIST. Since the 800 mg dose causes more pronounced toxic effects but equivalent ...

Meal kits and prepared meal delivery have changed weekday dinners for good. You don't have to run to the grocery store last minute or deal with the stress of figuring out what to make after a long ...

A study in the journal Pharmaceuticals has uncovered how specific genetic mutations in α 2 δ-1 and α 2 δ-3 proteins linked to autism spectrum disorders (ASD) alter neuronal functionality.

近期，宁夏医科大学基础医学院的 Liangying Zhang、Kun Xiao 等研究人员在《Scientific Reports》期刊上发表了题为 “SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT ...