At the Golgi, STING induces the phosphorylation of TBK1 and ultimately IRF3 leading to its translocation to the nucleus where phosphorylated IRF3 drives the transcription of type I IFNs. Each distinct ...

Several studies indicated that STF-66247 targets the trans-Golgi network (TGN): brefeldin ... Overall, STF-62247 induces autophagy — a process that has been implicated in a number of diseases ...

Background: The selective autophagic removal of mitochondria, lysosomes, Golgi are termed mitophagy, lysophagy, Golgiphagy, respectively. This study aims to investigate the role of organelle-specific ...

Plant autophagy is a vital cellular process that ... A study demonstrated that ATG8 is crucial for the recovery of the Golgi apparatus after heat stress, highlighting a non-canonical function ...

Using rotarod and Morris water maze tests, immunoblotting and immunofluorescence, Golgi-cox staining, and transmission electron microscopy, they assessed cognitive behavior, protein levels of synaptic ...

Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui 233030, China Clinical Testing and Diagnose Experimental Center, ...

Dr. Weickert will present Pacylex at the OBIO® Investment Summit and Early Technology Showcase February 5-7, 2025, at the Arcadian Court & Loft, Toronto Mr. Kamdar will present Pacylex at the PWMC ...

ER–Golgi transport: overexpression of LRRK2 may ... the deposition of both α-syn and LRRK2 protein aggregates. Autophagy: the α-syn A53T mutation seems to interfere with the chaperone-mediated ...

The evidence supporting the claims of the authors is solid. However, the observed changes in autophagy are moderate, the images were not fully represented by the quantification results, and some of ...