In vitro tests have demonstrated that second-generation antihistamines have improved H 1-receptor specificity and a slower dissociation rate compared with first-generation antihistamines ...

This observation led Swedish investigators to propose, in 1948, that there are two types of receptors sensitive to histamine, and close to two decades later British researchers gave the name H1 to ...

Abstract and Introduction Predicting and Establishing the Clinical Efficacy of a Histamine H Application of the Model Paradigm Conclusions References In vitro findings may correlate with the ...

Diphenhydramine – perhaps known most commonly as its brand name formulation Benadryl – is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal ...