On the basis of these facts, I speculated that a cholesterol-synthesis inhibitor, particularly a HMG-CoA reductase inhibitor, would be an effective cholesterol-lowering agent. In the 1960s ...

HMG-CoA reductase inhibitors, commonly referred to as statins, are the cornerstone of pharmacologic reduction of elevated low-density lipoprotein cholesterol. LDL-C is the main contributor to ...

In patients with hypercholesterolemia, ezetimibe added to ongoing HMG-CoA reductase inhibitor therapy significantly lowered total cholesterol, LDL-C, apolipoprotein B, and triglycerides and ...

Pravigard PAC (buffered aspirin and pravastatin sodium; Bristol-Myers Squibb, Princeton, NJ) is a copackaging of; Bristol-Myers Squibb, Princeton, NJ) is a copackaging of Pravachol and buffered ...

Our results indicate that ACAT2 has an important role in the response to dietary cholesterol, and suggest that ACAT2 inhibition ... measured mRNA levels of HMG CoA reductase (HMGR), the rate ...

Medically reviewed by Femi Aremu, PharmD Crestor (rosuvastatin) and Lipitor (atorvastatin) are the top medications for ...

Do not take two doses at the same time. Simvastatin and atorvastatin are cholesterol-lowering medications classified as HMG-CoA reductase inhibitors. They lower cholesterol levels by preventing ...

aldosterone antagonists and HMG-CoA reductase inhibitors. Early antithrombotic administration at the time of STEMI diagnosis consists of non-enteric-coated aspirin 162 mg to 325 mg (unless ...

They work by inhibiting an enzyme in the liver called HMG-CoA reductase and by inhibiting ... that same effect of causing liver damage. PCSK9 inhibitors are a new class of medications that may ...

Concomitant cisapride, pimozide, ergots, lomitapide, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). Concomitant colchicine (in renal or hepatic ...