Objectives To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss. Methods L-arginine was applied to three arthritis models (collagen-induced arthritis ...

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At the same time, because citrulline is not taken up by the liver, more citrulline in the low-protein diet enters the kidney to synthesize arginine to maintain normal physiological function.

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Besides its anticoagulant bioactivity, Zhao group isolated low-molecular-weight polyguluronate sulfate (LPGS) from alginate and administered LPGS at dose-levels ranging from 12.5 to 100 mg/kg on rats, ...

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We demonstrate that while wild-type Cas9 enforces stringent guanine selection through the rigidity of its interacting arginine dyad, xCas9 introduces flexibility in R1335, enabling selective ...

This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...