An expansion of a hexanucleotide repeat in the C9ORF72 gene can cause ALS. Here, the authors develop a high-fidelity RNA-targeting CRISPR system to suppress the repeat RNA expressed from the ...

When the lateral collateral ligament is completely torn, a surgical procedure is typically recommended to either repair or reconstruct the ligament. When the ligament is torn at the location of the ...

Objectives Evidence comparing the effectiveness of surgical and conservative treatment of symptomatic lumbar disc herniation is controversial. We sought to compare short-term and long-term ...

Objectives To evaluate the current evidence for the efficacy of corticosteroid injection and non-electrotherapeutic physiotherapy compared with control for treating lateral epicondylitis. Design ...