(3,32,118,129,134) CP3H Uncertain; modification of collagen IV structure. Ascorbate is required for reduction of lysyl hydroxylase enzyme bound Fe(III ... Regulation of the hypoxia inducible ...

Background The Ehlers-Danlos syndromes (EDS) are heritable disorders of connective tissue (HDCT), reclassified in the 2017 nosology into 13 subtypes. The genetic basis for hypermobile Ehlers-Danlos ...

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States ...

Structure-based drug design is the design and ... This approach significantly suppresses both anti-PD-1-responsive and -resistant tumor growth, particularly in brain tumors.

The team believes that the structure was in use until the 8th century BCE, the middle of the period when the Kings of Judah ruled. A scarab seal from the 8th century BCE uncovered during the ...

Figure 1. Overview of cellular steps leading to cardiac fibrosis. Following injury, cardiac fibroblasts are activated and transdifferentiated into myofibroblasts to replace dying cardiomyocytes. Dying ...

Mitochondrial integrity is central to efficient cellular energy production and cell survival in the face of environmental stresses, such as nutrient deprivation and ischemia, but also in response to ...

Busà Photography / Getty Images Many people believe that being wealthy means having a nice house, a late-model car, and a summer cottage, but the kind of money possessed by the wealthiest 1% of ...

From these indirect observations, scientists have calculated that the scorchingly hot inner core, with temperatures surpassing 5,000 degrees Celsius (9,000 Fahrenheit), makes up only 1 percent of ...

Cells were cultured in the M199 medium supplemented with 20% fetal bovine serum and 1% penicillin-streptomycin-glutamine at 37 °C with 5% CO 2 ... and increases in enzymatic pathways such as MMPs and ...