近日，美国得克萨斯大学西南医学中心Yunsun Nam团队揭示了癌症相关突变如何通过改变METTL3-METTL14复合体对RNA甲基化（m6A）的特异性来促进肿瘤发生。研究发现，METTL14的R298P突变能够改变m6A的序列偏好，优先修饰含有GGAU ...

Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, United States Department of Biochemistry and Structural Biology, University of ...

【导读】目前，靶向晚期透明细胞肾细胞癌（ccRCC）的治疗选择尚不充分。早期研究已表明，甲基转移酶样蛋白 14（METTL14）可通过 N6-甲基腺苷（m6A）的修饰来抑制 ccRCC ...

Objective Fat mass and obesity-associated protein (FTO), an eraser of N 6-methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear ...

Learning about your genetics and ancestry is easier than ever. All you need to do is choose from the many DNA ancestry tests available online, receive your kit and send back the required DNA samples.

此外，m6A 修饰与其他表观遗传机制，如 DNA 甲基化和组蛋白修饰密切相互作用，共同促进基因表达的精确调控。DNA 甲基化通常与基因沉默相关，而 m6A 修饰和组蛋白修饰主要集中在转录后调控。这三种修饰的协调作用在生物过程中起着至关重要的作用，调节细胞 ...

Comparison of that ancient DNA with modern human DNA showed that the two species had interbred and that people today still carry the genetic fingerprint of that intermixing. Since then ...

该研究首次揭示了 Mettl3 - m6A - NPY 轴在调节睡眠行为中的关键作用 ... 在分子层面，睡眠受多种机制调控，包括遗传学、DNA 和组蛋白修饰等，但 RNA 修饰在调节睡眠行为中的作用此前完全未知。 - 甲基腺苷（ ）是最丰富且可逆的 RNA 修饰之一，在神经元系统中 ...

The epigenetic mark 5-methylcytosine (5mc) can have an impact on DNA and increase the transcription of genes, while another marker known as N6-methyladenosine (m6A) affects mRNA transcripts, causing ...

西湖实验室研究员谢琦课题组一直从事肿瘤的靶向和免疫治疗研究，取得了一系列的研究成果，近年发表在Cell、Nature Biomedical Engineering、Cancer ...