Proteins containing a hydrophobic sorting signal are released into the inner mitochondrial membrane (IMM), while hydrophilic proteins are imported into the matrix with the help of the presequence ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial ...

The transfer consequently elevated mitochondrial membrane potential in the recipient cells. By introducing Alexander disease (AxD)-associated hotspot mutations (R79C, R239C) into GFAP gene of hPSCs ...

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

and metabolic dysfunction-associated fatty liver disease (MAFLD). Mitochondria are essential components of cells because they generate energy. They also play a crucial role in metabolism ...

Dysregulation at any level, such as excessive uptake or impaired efflux, leads to mitochondrial Ca 2+ overload, triggering ROS production, mitochondrial membrane potential loss, and permeability ...

The genes included those involved in the function of energy-producing mitochondria, lipid and iron metabolism, and the ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been ...