Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

Decidual inflammation was found to be a critical pathogenesis of OAPS, but the characteristic and regulator was unrevealed. We found significant monocyte/macrophage infiltration in decidua of OAPS ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

They found that macrophages expressing Gpnmb genes, which have historically been described as "pro-fibrotic" macrophages, were found in both types of lung injury, indicating that they may not be ...

Starting from the hypothesis that immune cells promptly respond to harmful stimuli, we used peripheral blood monocytes in order to characterise a distinct gene expression profile and to evaluate its ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

The role of the two monocyte subsets, classical monocytes (expressing CD115 ... to be almost exclusively mediated by osteoclasts (OC), multinucleated cells of myeloid origin generated from ...

Following myocardial infarction (MI), dying cardiomyocytes trigger a robust inflammatory response characterized by the infiltration of inflammatory cells, particularly monocytes/macrophages (Lavine et ...

The paper illustrates a valuable approach to generating TCR transgenic mice specific for known epitopes. Solid evidence validates the described pipeline for identification of TCRs from single-cell ...

Monocytopenia describes a low number of monocytes, a type of white blood cell. Monocytes are made in the bone marrow and account for 2% to 6% of white blood cells at any given time. They work ...