Email: pkubes{at}ucalgary.ca The established dogma regarding the different isoforms of nitric oxide has been that constitutively expressed nitric oxide synthase is an extremely important homeostatic ...

Nitric oxide is endogenously released in the airways by nitric oxide synthase. Functionally, two isoforms of this enzyme exist: constitutive and inducible. The former seems to protect airways from ...

In eukaryotes, PUFAs can be de novo synthesized through two independent biosynthetic pathways: the desaturase/elongase pathway and the PUFA synthase pathway. Among them, PUFAs synthesized through the ...

Pseudouridine synthases catalyze the isomerization of specific uridines to pseudouridine in a variety of RNAs, yet the basis for recognition of the RNA sites or how they catalyze this reaction is ...

Mutations in the genes for the phosphatase laforin or the E3 ubiquitin ligase malin can cause LD. By depleting PTG, an activator of the glycogen chain-elongating enzyme glycogen synthase (GYS1), in ...

Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

Drake is making waves again, but this time it’s not for his music. Popular YouTuber and reaction channel creator No Life Shaq has taken issue with the rapper after discovering he was named in a ...

Allergies are an immune system reaction to substances called allergens. The cause a range of symptoms from a stuffy nose to itchy eyes to difficulty breathing. How long allergies last varies based on ...

2017). PMX is an antifolate that simultaneously inhibits the synthesis of both purines and pyrimidines (Shih et al., 1997). PMX and its polyglutamated derivatives inhibit thymidylate synthase (TYMS), ...

Reaction formation may be a temporary coping mechanism, but it’s unproductive in the long run. It ignores underlying beliefs or challenges that need to be addressed, which can hurt mental health.

Brad Brownell and the Clemson men's basketball team have done it again. It was another historic night for the No. 21 Tigers, who took down the No. 2 Duke Blue Devils 77-71 in front of their home crowd ...