It is one of three related, PKA-regulated inhibitors of protein phosphatase-1 (PP1). These inhibitors seem to have appeared in early vertebrate ancestors, possibly Gnathostomes. DARPP-32 has ...

The adeno-associated virus (AAV) based therapy delivers a gene coding for a therapeutic protein, known as inhibitor-1 or I-1, which blocks the activity of protein phosphatase 1 (PP1), an enzyme ...

It delivers a gene coding for a therapeutic protein, called inhibitor-1 or I-1, which blocks the activity of protein phosphatase 1 (PP1), thought to play a role in the development of heart failure.

The pharmacological reestablishment of calreticulin exposure may ameliorate the efficacy of chemotherapy, and the development of non-toxic PP1-inhibitory molecules that can induce calreticulin ...

In addition, ATF4 promotes PPP1R15A expression, which subsequently induces the expression of DNA damage-inducible 34 (GADD34), a regulatory subunit of protein phosphatase 1 (PP1); this results in ...

3, 2024 — A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed ...

Long-term depression (LTD) encompasses a family of synaptic plasticity mechanisms that can be triggered by the synaptic or pharmacological activation of glutamate receptors — in particular ...