Unfortunately, unlike animal studies, neuropathic pain mechanisms in humans remain largely unclear; current clinical and neurophysiological research has proposed various mechanisms for each type ...

The prescription pills, sold under the brand name Journavx and made by Vertex Pharmaceuticals, are taken twice a day and ...

The Phase IIa results continue a surge of momentum in a treatment space that last week saw the approval of Vertex’s Journavx ...

However, many virally-mediated states, such as post-viral chronic pain conditions associated with influenza, as well as Long COVID syndrome, are characterized by long-lasting, non-dermatomally ...

In contrast to acute pain, which has important warning and protection functions, chronic pain is a maladaptive mechanism that continues long after recovery from an injury or disease. Treatment of ...

Pain is a major source of human suffering ... However, the neuronal mechanisms underlying GBOs have remained poorly understood, limiting the use of GBOs in clinical applications.

Indian Institute of Science scientists have discovered how specific brain regions collaborate to manage chronic pain in mice, particularly from chemotherapy. Key findings show the lateral ...

A new pain relief drug, suzetrigine, is a prescription pill that’s taken every 12 hours after a larger starter dose. It will ...

FDA approves suzetrigine, a non-opioid painkiller that blocks sodium channels, offering potent relief without addiction risks.

While these findings help explain why pain perception can be subjective, Barik notes that more research is needed to understand if similar mechanisms apply to other types of chronic pain ...

An effort two decades in the making, Vertex Pharmaceuticals Inc.’s suzetrigine gained U.S. FDA approval as the first drug targeting the NaV1.8 pain signal. Branded Journavx, the oral small molecule is ...