Biosynthesis is the generation of natural products through enzymatic reactions, as in cellular metabolism. Successive enzymatic reactions by a number of enzymes are generally required to achieve a ...

The authors identify new mechanisms that link a PIK3R1 mutant to cellular signaling and division in Activated PI3 Kinase Delta Syndrom 1 and 2 (APDS1/2). The conclusion that this mutant serves as a ...

PI3K signalling mediates responses to a myriad of cues, including growth factors, hormones such as insulin, and processed antigens, and so recent discovery that genetic perturbation of PIK3R1 in ...

These included nucleotide metabolism pathways (e.g., thymine catabolism, thymidine de novo biosynthesis, and homocysteine metabolism), DNA repair pathways ... As shown in Figure 2C, amplifications ...

Skeels using metabolomics and transcriptomics. It aims to identify metabolic pathways and differentially expressed genes related to flavonoids and anthocyanins biosynthesis. Results: The PP (purple ...