TB Alliance has disclosed new ATP-dependent Clp protease ClpP1P2 complex (Mycobacterium tuberculosis) inhibitors reported to be useful for the treatment of tuberculosis.

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

The general strategy for therapeutically targeting proteases is to identify a specific inhibitor — generally a small molecule — that blocks the active site. As discussed below, discovery ...

In this video, Aruna Padmanabhan, MD, discusses the evaluation of PI3K inhibitor combinations as first-line treatment for patients with metastatic breast cancer.

Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany German Center for Infection Research (DZIF), Hannover-Braunschweig Site, ...

Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan ...

2014). It was observed that blocking cathepsin-L can prevent SARS-CoV-1 infection, and that a combination of EST (a cathepsin inhibitor) and camostat can accomplish total viral entrance and ...

Originally published in the Mercury's sister publication The Stranger, as part of its Love & Sex Issue.] On July 3, 1981, the ...

Pseudoscience has recently re-emerged in the U.S. While much of it concerns vaccines, an "oldie" is again making the rounds: ...

Mr. Iwicki stated, “I am proud of the work we have done at KALA utilizing our MSC-S platform, and I am very excited about the potential of our lead product candidate, KPI-012 for the treatment of PCED ...