Rab GTPases are a family of proteins that play a significant role in regulating membrane trafficking by controlling the transport of vesicles, which are small membrane-bound sacs that carry ...

Rab proteins achieve this by reversibly associating with lipid membranes through a process that is known as Rab membrane cycling. Active GTP-bound prenylated Rab proteins are present in membranes.

Most-abundant zymogen granule proteins. ‡ Different isoforms present ... made in the identification and validation of several new Rab GTPases on ZGs, as well as in the discovery of ion channels ...

Key regulators of this process include the Rab family of GTPases, SNARE proteins, and the endosomal sorting complex required for transport (ESCRT). Read the full story here.