Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

In this study we identified a novel mechanism regulating the function of liver T-ICs. We found that epigenetic modification of miR-429 can promote the properties of liver T-ICs by targeting the Rb ...

The researchers then focused on novel mechanisms that confer resistance to palbociclib, identifying PRC2.1. Genetic and pharmacological disruption of PRC2.1 function, but not related PRC2.2, leads to ...

We found that nuclear DLEU2 directly binds HBx and the histone methyltransferase enhancer of zeste homolog 2 (EZH2), the catalytic active subunit of the polycomb repressor complex 2 (PRC2) complex.

This approach revealed that mutations in mitochondrial function or the Polycomb complexes rescued slow proliferation in palbociclib. We could recapitulate these positive genetic interactions ...

The liver performs hundreds of vital functions, including converting nutrients from food into energy, filtering toxins from the blood, and producing bile, a key substance in digestion and waste ...

The amino acid sequence, encoded by its gene, determines a protein’s structure and function. Newly synthesized proteins can be modified by post-translational modification, altering its protein ...

"The most common type of MPNSTs initiate by losing the function of three important genes, called tumor suppressor genes: NF1, CDKN2A and PRC2 (either SUZ12 or EED). We have been fortunate that ...

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, established new approaches to both CNS tumor nomenclature and grading, emphasizing the ...

"The most common type of MPNSTs initiate by losing the function of three important genes, called tumor suppressor genes: NF1, CDKN2A and PRC2 (either SUZ12 or EED). We have been fortunate that ...