P62/SQSTM1 directly modulates these pathways through complex formation with TRAF6 ... Western blot analysis of osteoclast lysates revealed increased TNFα-induced extracellular signal-regulated kinase ...

We also demonstrate that the autophagic target SQSTM1/p62 is decreased in SOD1-G93A microglia after a short stimulation of P2X7, but increased after a sustained challenge. These effects are prevented ...

Western blot analysis and immunofluorescence assay were used to determine the levels of P62/SQSTM1 and LC3, and autophagic U937 cells were isolated by ... Lamkanfi, C.A. Dinarello, P.C. Doherty, T.D.