Nature12y
IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect
In this study, we show that IL-22 deficiency in donor T cells can decrease the severity of aGVHD, while limiting systemic and local inflammation in aGVHD target organs. In addition, we found that ...
Fred Hutch5mon
Jarrod Dudakov, PhD
Targeted thymic regeneration could also significantly benefit individuals with T cell deficiencies due to aging, genetic causes (such as severe combined immunodeficiency), infectious diseases (such as ...