Binding of both the RNA-binding protein TDP-43 and the m6A RNA modification chemical tag has been found to be altered on genes that are dysregulated in HD. Further, TDP-43 pathology, classically ...

Binding of both the RNA-binding protein TDP-43 and the m6A RNA modification chemical tag has been found to be altered in genes that are dysregulated in HD. Further, TDP-43 pathology, classically ...

Binding of both the RNA-binding protein TDP-43 and the m6A RNA modification chemical tag has been found to be altered on genes that are dysregulated in HD. Further, TDP-43 pathology, classically ...

This important study reveals a new mechanism for gene regulation in neurons by an RNA binding protein called RBM20 previously studied in the heart. The methods used are compelling, including the ...

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Halo was knocked in to a single TDP-43 allele at the N-terminus of the protein, before exon 2. B) Microscopy validation of Halo-TDP-43 localization to nucleus. Halo in pink, ConA lipid dye in green, ...

Delve into the increasingly dynamic landscape of ALS treatment development with thirteen companies advancing candidates in ...

Evidence for such a prion-like propagation mechanism has now spread to the major misfolded proteins, superoxide dismutase 1 (SOD1) and the 43 kDa transactive response DNA binding protein (TDP-43), ...