Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Macrophages are key effector cells that play a central ...

Correspondence to Professor Fuming Qiu, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; qiufuming{at}zju.edu.cn; ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

Alveolar macrophages (AMs) are critical components of the innate defense mechanism in the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow, can phagocytose ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

Volume 3 Issue 2封面解读Xiaodong LuanIn rodents, the heart possesses the remarkable ability for regeneration within the ...

Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer ...

To test this hypothesis, we analysed the effect of FFA on synovial fibroblasts (SF), human chondrocytes and endothelial cells. We also investigated whether the toll-like receptor 4 (TLR4), which can ...

Despite the recent rise in herbal supplement use, research suggests certain supplements may pose risks for patients with ...

3Department of Pathology, Yale School of Medicine, New Haven, Connecticut. 4Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. 5Yale Center for Precision Cancer Modeling, Yale ...

最近的研究发现ECSIT在非免疫细胞和免疫细胞中对肿瘤发生有重要影响。肠道上皮细胞中ECSIT的缺失引起线粒体功能损伤并促进代谢重编程，谷氨酸代谢增加引起α-酮戊二酸/琥珀酸比率升高，进而促进TET去甲基化酶激活并诱导选择性翻译起始因子eIF4A1/ ...