This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

After electrophoresis, proteins were transferred onto PVDF membranes (ThermoFisher Scientific) using an iBlot 2 Dry Blotting System. After blocking with Tris-buffered saline with 0.1% Tween-20 and 5% ...

The membrane was incubated overnight at 4°C with anti-Rac1 or anti-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) antibody. After washing in Tris-buffered saline with Tween (TBST), horseradish ...

2012). An aliquot of 24 µL of 25 mmol/L pyrogallol solution was added to a tube containing 100 µL kombucha samples and 4.50 mL of Tris-HCl-EDTA buffer (0.05 M, pH 8.20). The optical density (OD) was ...

Having shown last week that its opioid alternative can reduce post-surgery pain, Tris Pharma is back with another slice of clinical data to show that the drug is less likely to be abused.

There is a global shortage of saline intravenous (IV) fluids used to treat common medical conditions in humans and animals. A Newcastle vet noticed Lifeblood discarding small amounts of saline ...

Phase 3 trial shows promising pain relief for acute pain patients Tris Pharma, Inc. has announced positive results from its ALLEVIATE-1 phase 3 clinical trial evaluating cebranopadol for treating ...

Newly released satellite imagery shows Israel Defense Forces (IDF) construction taking place within the demilitarised buffer zone that separates the Israeli-occupied Golan Heights from Syria.

This post expresses the views and opinions of the author(s) and not necessarily that of The Saline Post management or staff. When I read the recent post, Why Do We Need a Dam Anyway?, I realized that ...

Tris Pharma has pointed to a phase 3 win for its pain relief drug as demonstrating the candidate’s potential to help resolve the opioid crisis. The company tested cebranopadol, a dual nociceptin ...