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This manuscript from Clayton and co-authors aims to clarify the molecular mechanism of BRAF dimer selectivity. Indeed, first generation BRAF inhibitors, targeting monomeric BRAFV600E, are ineffective ...

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, United States Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of ...

micro-RNA-mediated inhibition of p27 translation emerges as a novel mechanism that can reduce p27 in some human cancers. p27 proteolysis is initiated by several different mechanisms. Tyrosine (Tyr ...

Introduction: Ulcerative colitis (UC), a form of inflammatory irritable bowel disease, is characterized by a recurrent and persistent nonspecific inflammatory response. Polydatin (PD), a natural ...

Attribution (BY): Credit must be given to the creator. Inhibition of the mitochondrial deubiquitinating (DUB) enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment ...

Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China ...

John Seymour, MBBS, FRACP, PhD, explains the mechanism of action of BCL-2 inhibitors like venetoclax. John Seymour, MBBS, FRACP, PhD, director of hematology at the Peter MacCallum Cancer Center and ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...

The findings shed light on how socio-sexual preferences adapt for survival and health in mammals. Understanding these neural mechanisms could inform studies on social behavior and stress responses in ...