As far back as 1873, Kölliker 1 observed the existence of osteoclasts in the periosteum of normal bone. Lacroix 2 also made several references to the presence of periosteal osteoclasts during ...

The enzyme aconitate decarboxylase 1 (Acod1) is known to link the cellular function of monocyte-derived macrophages to their metabolic status. As osteoclasts derive from the monocyte lineage, we ...

Osteoporosis is typically treated with orally administered drugs, which may take up to a year to have a noticeable effect. A ...

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

They observed that Fam102a promoted the differentiation of both osteoclasts and osteoblasts, and deletion of Fam102a resulted in an osteoporosis-like condition in mice, characterized by low bone ...

Medically reviewed by Allison Herries, RDN Manganese is a trace mineral, meaning your body needs it in smaller amounts than ...

TNF-α, a master cytokine in human IBD, causes bone erosions in experimental models and these effects are exerted by osteoclasts. Other TNF-related cytokines such as receptor activator of nuclear ...

The Royal Osteoporosis Society explain what osteopenia and osteoporosis mean and how diet, lifestyle and genetic factors can affect bone density.

Feb. 10, 2025 — Rapid weight loss affects muscle mass and can increase the risk of osteoporosis. But now there is good news for people taking weight loss medication who may be at risk. A new ...

RANKL binds to RANK on osteoclast precursors causing differentiation to mature to osteoclasts, which in turn causes bone resorption, releasing calcium into the circulation. The CaSR is a G-protein ...