Neurological diseases are highly heterogeneous; however, they share a common pathogenesis, that is, the aberrant accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER).

在肿瘤的世界里，癌细胞就像一群狡猾又顽强的 “侵略者”，它们能在恶劣的环境中不断适应、发展壮大。肿瘤内部常常处于缺氧、营养匮乏的状态，还伴随着各种致癌突变，这就像是给癌细胞设置了重重 “障碍关卡”。但癌细胞却有自己的 “生存秘籍”—— 激活未折叠蛋白反应（Unfolded Protein Response，UPR），以此来维持内质网（Endoplasmic ...

These patterns appeared to co-localize with the endoplasmic reticulum (ER) and with ER-PM contact sites, and closely resembled patterns caused by over-expression of the ER-PM tether protein ...

The ER is an intracellular organelle consisting of a membranous network that extends throughout the cytoplasm of the cell and is contiguous with the nuclear envelope. In eukaryotic cells, the ER ...

New research details the subcellular structures in neurons that enable signals to be transmitted from where they are received at specific sites on dendrites to the decision-making cell body located ...

The first clue about the possible connection between brain and muscle cells came when Janelia scientists noticed something ...

This is a python script tool to automatically find active TCPInterface servers, list them and select the servers you want to add to Reticulum config automatically ...

Results As well as inducing transcriptional modules implicated in antimicrobial responses, IL22 also coordinated an endoplasmic reticulum (ER) stress response transcriptional programme in colonic ...

The endoplasmic reticulum (ER) is the site at which secreted proteins (such as the hormone insulin) and membrane-bound proteins are folded. ATP-dependent chaperones within the ER help proteins fold.

Key Laboratory of Smart Biomaterials of Zhejiang Province and Key Laboratory of Biomass Chemical Engineering of the Ministry of Education of China, College of Chemical and Biological Engineering, ...

A study published in Scientific Reports found that cannabidiol (CBD) disrupts lipid metabolism and induces apoptosis in ...