Symptoms of acromegaly usually begin sometime after puberty, most commonly between the ages of 40 and 50. The disease causes a person's bones to enlarge — most notably, in the hands, face and feet.

Biochemical control of acromegaly in noncured patients is usually defined as serum growth hormone (GH) levels <2.0 µg/l, plus normal-for-age serum levels of insulin-like growth factor I (IGF-I).

Occasionally patients with childhood or young adult onset pituitary adenomas, most often with acromegaly, carry an AIP mutation, although no known family history of pituitary adenomas is available.

Occasionally patients with childhood or young adult onset pituitary adenomas, most often with acromegaly, carry an AIP mutation, although no known family history of pituitary adenomas is available.