Pathogenic mechanisms in scleritis are poorly understood, but enzymatic degradation of collagen fibrils by resident cells and infiltrating leukocytes seems to be a key feature. Several forms of ...

Infectious scleritis is a severe and potentially vision-threatening inflammation of the sclera caused by microbial invasion. Unlike autoimmune scleritis, infectious scleritis is less common with a ...

Moreover, this regulatory molecule has been intimately involved in the treatment of autoimmune diseases (7). Elucidating the immunoregulatory mechanisms and roles of CTLA-4 in autoimmune diseases will ...

Aims To describe and compare clinical features, complications and outcomes in patients with granulomatosis with polyangiitis (GPA)-associated scleritis with those seen in idiopathic and other ...

Several types of dermatitis involve an overreaction from the immune system, but it is not an autoimmune condition. An autoimmune disease is the result of the immune system mistakenly attacking the ...

Researchers discovered a previously unknown mechanism that may drive tissue ... block this harmful pathway in patients with autoimmune and inflammatory diseases. Results are published in Nature.

These results confirm the strong Phase 1 and preclinical data package, underscoring the potential breadth and depth of Nck modulation, a completely novel mechanism in autoimmune disease.

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

Research in mice has shown that NPSLE-like symptoms and olfactory impairment might be induced by autoimmune mechanisms that target specific areas of the brain, but this has not been explored.

The Clean Development Mechanism (CDM), defined in Article 12 of the Protocol, allows a country with an emission-reduction or emission-limitation commitment under the Kyoto Protocol (Annex B Party) to ...