Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Quantification and characterization of these multiple HML-2 insertions in the human chromosome has been challenging due to their size, sequence homology with each other, and their repetitive nature.

We do not understand the nature of the factors that control the regional distribution of recombination along chromosomes, the mechanisms that control chromatid compaction and interference nor the ...

Women are born with two X chromosomes and inherit one from each parent. But in every cell of their body, just one X chromosome is needed—so the other is randomly inactivated. Some cells use only ...

Summary: New research shows that female mice expressing only a maternal X chromosome experience faster brain aging and cognitive decline compared to those expressing both maternal and paternal X ...

A key target of the APC is securin, the destruction of which initiates chromosome segregation by unleashing the protease separase, which destroys sister-chromatid cohesion. The APC also ...

This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chromosome segregation relies on kinetochores ...

The wide variety of congenital anomalies often accompanying constitutional aplastic anemia has led to its recognition as a distinctive syndrome. Congenital malformations have been the outstanding ...

Chromatid aberrations in peripheral leukocytes ... Moreover, although it is not known in what stage the chromosomes of reticuloendothelial-tissue stem cells or precursors of peripheral leukocytes ...