Derepression of C-pro transcription in sir2 causes RNA PolII to push the Mcm helicase complex from its normal location (arrow labeled “A”) to the right, with the most prominent signals arising at the ...

This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and ...