【导读】 S-棕榈酰化是一种可逆的、广泛存在的翻译后修饰，但人们对其在调控铁变态反应中的作用却知之甚少。在这项研究中，团队阐明了铁变态反应的重要调节因子GPX4在半胱氨酸66上可逆地发生棕榈酰化。

【导读】雌激素受体阳性（ER+）乳腺癌约占病例的 70%。靶向雌激素的内分泌疗法是 ER+ 乳腺癌的一线疗法。然而，约有一半的患者会对这些疗法产生耐药性，从而导致生存率降低。

Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China University of the Chinese ...

We further treated the cells with CHIR99021, an activator of the Wnt signaling pathway. The results showed that CHIR99021 activated the GSK3β/β-catenin signaling pathway and reversed the PFOA-induced ...

Conclusion: Taken together, our results indicated that DSI could protect against ferroptosis to attenuate renal fibrosis by activating the SIRT1/GPX4 pathway. It is expected to be a potential agent to ...

题为“circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4”，本研究中，环状RNA测序分析显示，circASAP1在肾透明细胞癌 ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

The discovery of ferroptosis—a regulated form of cell death characterized by glutathione depletion, inactivation of glutathione peroxidase 4 (GPx4), and iron-dependent propagation of LPO—has ...