Endometrial cancer (EC) ranks as the second most prevalent gynecologic malignancy globally, with approximately 189,000 new ...

【导读】S-棕榈酰化是一种可逆的、广泛存在的翻译后修饰，但人们对其在调控铁变态反应中的作用却知之甚少。在这项研究中，团队阐明了铁变态反应的重要调节因子GPX4在半胱氨酸66上可逆地发生棕榈酰化。2025年1月20日， 深圳湾实验室尹成骞教授团队在期刊 ...

This study aimed to investigate the pharmacological activity and underlying MOA. Conclusion: ORes inhibits breast cancer cell growth by inducing ferroptosis through suppression of the ...

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China University of the Chinese ...

Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

We further treated the cells with CHIR99021, an activator of the Wnt signaling pathway. The results showed that CHIR99021 activated the GSK3β/β-catenin signaling pathway and reversed the PFOA-induced ...