Lonza’s bYlok® technology is changing the way bispecific antibodies are designed. Achieving the correct heterodimerization of light and heavy chains during bispecific production can be challenging, ...

Ab Studio’s ‘imbalanced’ bispecific antibodies (BsAbs ... a unique engineered Fc domain with complementary ‘knob into hole’ design that favors formation of the desired bispecific ...

Another study explored the use of bovine knob domains to create bispecific antibodies that can target multiple antigens simultaneously. By inserting these domains into specific regions of antibody ...