A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

These findings provide a solid foundation for further exploration of the regulatory mechanisms underlying lysosome transport. Their findings were published in Structure on Dec. 30, 2024.

Lysosomes are subcellular organelles that are mainly responsible for degradation of proteins internalized by cells by endocytosis and phagocytosis. Upon uptake, proteins and soluble components ...

It then detaches from the first lysosome and transfers to the second lysosome, forming a thin and tubular intermediate structure during the transfer. Figure 2. The molecular composition and regulation ...

Lysosomes are organelles found within nearly ... elastin and other complexes to support the overall structure and function of a cell. Integral to this study is MYO18B, a gene most often found ...

The team believes that the structure was in use until the 8th century BCE, the middle of the period when the Kings of Judah ruled. A scarab seal from the 8th century BCE uncovered during the ...

Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have ...

Earth's inner core may actually have two distinct layers. (alexlmx/Canva Pro) "We found evidence that may indicate a change in the structure of iron, which suggests perhaps two separate cooling events ...