1. Lactate, as a metabolite of cellular adaptation to hypoxic environments, is mainly produced by glycolysis. MCT1 and MCT4 are mainly responsible for the cellular uptake and release of lactate.

Therefore, exploring these factors and the cross-conversion between glycolysis and mitochondrial activity in various cells in the tumor microenvironment is essential for understanding the metabolic ...

Recent findings about the new roles of lactate have changed our understanding of this end product of glycolysis or fermentation that was once considered only a waste product. It is now well accepted ...