Monocytopenia describes a low number of monocytes, a type of white blood cell. Monocytes are made in the bone marrow and account for 2% to 6% of white blood cells at any given time. They work ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

The paper illustrates a valuable approach to generating TCR transgenic mice specific for known epitopes. Solid evidence validates the described pipeline for identification of TCRs from single-cell ...

They found that macrophages expressing Gpnmb genes, which have historically been described as "pro-fibrotic" macrophages, were found in both types of lung injury, indicating that they may not be ...

Results were considered significant when p < 0.05. In this study, we demonstrated that IL-17 R expression displayed a peculiar pattern, with IL-17RA, and IL-17RC increased expression in monocyte and ...

We showed that monocyte-derived tolDCs generated by DEX and VitD2 displayed better regulatory ... and Th17 cytokine production and higher proliferation upon TCR stimulation compared to euglycemic ...