Federal officials on Thursday approved a new type of pain pill designed to eliminate the risks of addiction and overdose ...

The company tested cebranopadol, a dual nociceptin/orphanin FQ peptide (NOP) receptor and µ-opioid peptide (MOP) receptor agonist, in a late-stage trial on patients who have undergone cosmetic ...

The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the ...

Université de Bordeaux, INCIA, UMR 5287, 33076, Bordeaux, France CNRS, INCIA, UMR 5287, 33076, Bordeaux, France Université de Bordeaux, IMN, UMR 5293, 33076 ...

Mu-opioid receptor (MOR) functions as a part of complex opioid system and supports both homeostatic and hedonic control of eating behavior. Thirteen patients with AN and thirteen healthy controls (HC) ...

The quality of immunoassays depends on the specificity and affinity of the receptor molecule (usually a monoclonal antibody ... critical blind spot in the tools available for field and laboratory ...

Natural slowdown of respiration and heart rate is caused by slow wave sleep, when body is not moving. The MHb and rostromedial tegmental nucleus are known for high amount of mu-opioid receptors. Both ...

The kappa opioid receptor was cloned in 1993 (Meng et al., 1993), while its pharmacological identification spans more than two-decades before. Portoghese and others proposed more than a single opioid ...